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Stimulants and depressants Stimulants and depressants affect the synapses between neurones in the nervous system: stimulants cause more neurotransmitter molecules to diffuse across the synapse depressants stop the next neurone sending nerve impulses they bind to the receptor molecules it needs to respond to the neurotransmitter molecules

North America held approximately 14.8% of the global cigarette inner frame market in 2025, driven primarily by the United States, where Altria Group and Reynolds American Inc

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